Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning
نویسندگان
چکیده
منابع مشابه
BDNF deletion or TrkB impairment in amygdala inhibits both appetitive and aversive learning.
Brain-derived neurotrophic factor (BDNF) is known to have an integral role in establishing stable memories after learning events. The neuroplasticity induced by Pavlovian fear conditioning has likewise been shown to rely on interactions between BDNF and its principal receptor, tyrosine kinase receptor B (TrkB), in the amygdala after training. Although the necessity of amygdala bdnf expression a...
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Prenatal cocaine exposure causes profound changes in neurobehavior as well as synaptic function and structure with compromised glutamatergic transmission. Since synaptic health and glutamatergic activity are tightly regulated by brain-derived neurotrophic factor (BDNF) signaling through its cognate tyrosine receptor kinase B (TrkB), we hypothesized that prenatal cocaine exposure alters BDNF-Trk...
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Adult Lepidoptera are capable of associative learning. This helps them to forage flowers or to find suitable oviposition sites. Larval learning has never been seriously considered because they have limited foraging capabilities and usually depend on adults as concerns their food choices. We tested if Spodoptera littoralis larvae can learn to associate an odor with a tastant using a new classica...
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ژورنال
عنوان ژورنال: Translational Psychiatry
سال: 2012
ISSN: 2158-3188
DOI: 10.1038/tp.2012.128